Yes. SYLK has been subject to thorough product testing and has passed all condom compatibility tests. SYLK is a natural, water-based lubricant made from plant-based ingredients with no nasty chemicals. It is safe to use with condoms and sex toys. The unique feel of SYLK enhances sensitivity, which is especially good when using condoms. As latex sensitivity can be increased with friction, extra lubricant should always be used with condoms. We would recommend that you put a drop of SYLK lube on the tip of the condom and then massage plenty on the outside.